This research article investigated the impact of low-speed uphill exercise on lactate levels and brain-derived neurotrophic factor (BDNF) in rat brain regions crucial for memory and learning, specifically the cortex and hippocampus. The study found that prolonged uphill exercise, even at a low speed, significantly increased both lactate and BDNF in these brain areas, a result not observed with flat exercise. Furthermore, the research demonstrated that elevated blood lactate levels, whether induced by exercise or direct injection, correlated with increased brain lactate. These findings suggest that low-speed uphill exercise offers a way to enhance brain function by promoting lactate production and BDNF expression.
SOURCE
Masaki Takimoto, Taku Hamada,
Low-speed uphill exercise increases lactate and brain-derived neurotrophic factor in brain regions for memory and learning,
Neuroscience Research,
2025,
,
ISSN 0168-0102,
https://doi.org/10.1016/j.neures.2025.02.004.
(https://www.sciencedirect.com/science/article/pii/S0168010225000306)
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